自组装的mogroside v nanomicelle系统提高了 magnolololol 的口服生物可用性
Chengzhi Liu1, Lingyi Ren2, Niu Liu1
1Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, College of Animal Science and Technology, Guangxi University, Nanning, Guangxi 530004, China; Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning 530004, China.
Food chemistry
|May 28, 2025
概括
摩格罗化物V (MV) 形成纳米细胞,以改善磁醇 (MAG) 的口服吸收. 这种天然载体显著提高了MAG的生物可用性,为食品应用提供了新的策略.
科学领域:
- 药理学 药理学是指药理学的学科.
- 材料科学 材料科学 材料科学
- 食品科学 食品科学 食品科学
背景情况:
- 由于其疏水性质,马格诺洛尔 (MAG) 的口服生物利用性很差.
- 摩格罗斯V (MV),一种天然的素,被用作甜味剂,但其作为药物载体的潜力尚未被探索.
- 开发有效的输送系统对于增强像MAG.这样的疏水化合物的治疗和功能性质至关重要.
研究的目的:
- 调查Mogroside V (MV) 作为一种自我组装的载体,用于增强 magnolol (MAG) 的口服生物可用性.
- 合成和表征MAG-MV自组装纳米细胞 (SAM),以改善MAG输送.
- 评估MAG-MV SAM的生物安全性和肠道吸收增强.
主要方法:
- 使用超声波分散合成了MAG-MV自组装纳米细胞 (SAM).
- 确定了微粒大小,封装效率和MV的临界微粒度 (CMC).
- 使用Caco-2细胞单层的体外研究和体内药理动力学研究进行了体外研究.
主要成果:
- MAG-MV SAM成功合成了175.47nm的粒子大小和89.39%的封装效率.
- MV显示CMC为2.64 mg/mL,表明其自组装能力.
- MAG-MV SAM显示出出色的生物安全性,增强了Caco-2细胞的透性,并且MAG口服生物可用性增加了243%.
结论:
- 摩格洛V (MV) 是一个有前途的天然载体,用于像磁 (MAG) 这样的疏水性物质.
- MAG-MV SAM有效地改善了MAG的口服生物可用性和肠道吸收.
- 这种方法为增强MAG在食品和制药应用中的物理化学特性提供了一个可行的策略.
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