基于自组装和核心外结构的双重向化疗免疫疗法联合递送系统.
Yifei Guo1, Lijuan Ding1, Xiaoxue Lang1
1State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 151 Malianwa North Road, Haidian District, Beijing 100193, China.
概括
这项研究开发了用于化学免疫治疗的双重向纳米颗粒,增强了乳腺癌治疗. 与传统化疗相比,该新系统显著提高了抗瘤疗效.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 癌症研究 癌症研究
背景情况:
- 线粒体介导的亡是一种关键的抗瘤策略.
- 提高抗瘤疗效需要改进的药物递送系统,以向癌细胞和线粒体.
- 化疗免疫疗法为乳腺癌治疗提供了一个有前途的方法.
研究的目的:
- 开发用于乳腺癌化学免疫治疗的双重向联合交付系统.
- 为了结合切拉斯特 (CEL),雷斯基莫德 (R848) 和向配体,增强抗瘤效果.
- 在临床前乳腺癌模型中评估开发的纳米颗粒的疗效.
主要方法:
- 塞拉斯特罗尔,雷西基莫德和三基的自我组装成核心纳米粒子 (TCR).
- 用 hialuronic 酸装饰 TCR 纳米粒子,以形成具有双重定位的 H/TCR NP.
- 纳米粒子尺寸,结构和稳定性的表征.
- 在4T1瘤携带的小鼠模型中的体内评估.
主要成果:
- H/TCR NPs表现出一个统一的核心-结构 (~164 nm) 具有良好的稳定性.
- 这些纳米颗粒在线粒体中增加了积累,这是由于三素向.
- 观察到显著的瘤抑制 (66.5%),表现优于帕克利塔塞尔.
- 双准系统有效地通过线粒体介导的亡促进了塞拉斯特的抗瘤活性.
结论:
- 具有双重准能力的联合递送纳米粒子显示了联合抗瘤效应.
- H/TCR NPs为乳腺癌化疗免疫疗法提供了一个有前途的战略.
- 这种方法有可能解决乳腺癌治疗和克服耐药性的未满足需求.
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