预突触释放调节α2受体和乌罗利:系统EA和中央健康特性之间的桥梁
Veronica Torre1, Emanuela Marchese2, Edward Willison3
1Department of Pharmacy, University of Genoa, Viale Cembrano 4, Genoa 16148, Italy.
概括
酸 (EA) 的代谢物,特别是乌罗立A,激活中央α2自身受体,解释EA的神经保护作用. 肠道微生物组的变化支持了这一机制,将EA的健康益处与诺亚上腺素联系起来.
科学领域:
- 神经药理学神经药理学
- 肠道微生物组研究研究
- 自然产品化学 自然产品化学
背景情况:
- 埃拉基酸 (EA) 显示出神经保护的潜力,可能是通过noradrenergic路径的α2自身受体.
- 由于EA的中枢神经系统生物可用性较差,限制了其直接作用.
- 乌罗利是EA的代谢产物,具有更高的生物可用性,这表明它在EA的核心作用中发挥了作用.
研究的目的:
- 调查乌罗利是否调解埃拉基酸的中央神经保护作用.
- 为了确定哪些乌罗利与α2受体亚型相互作用.
- 探索EA管理,肠道微生物组和中央诺亚氨酸适应之间的联系.
主要方法:
- 计算建模和体外试验测试以评估乌罗立α2受体相互作用.
- 在体内研究,包括在小鼠中长时间服用配方EA.
- 分析肠道微生物组的组成及其与中央神经化学变化的相关性.
主要成果:
- 乌罗立A (UroA) 已证明可以结合和激活α2受体亚型.
- 乌罗立B和C与α2受体没有显著的相互作用.
- 慢性EA的使用在小鼠中诱导了α2自身受体脱敏和密度降低.
- 与肠道微生物组向UroA生产转移相关的中心适应.
结论:
- 乌罗立A被提议作为一个关键的系统效应因子,调解EA的中央神经上腺素效应.
- 肠道微生物组在产生影响中枢神经系统的乌洛素方面发挥着至关重要的作用.
- 诺拉德林被证实是EA的健康益处的调解者,通过Urolithin A.
关键词:
埃拉基酸是什么意思 埃拉基酸是什么意思埃拉基酸微散微散的方法诺亚上腺素 (noradrenaline) 是一种上腺素.乌罗立是一种酸盐.克洛尼迪因 (clonidine) 是一种类型的药物.预突触的α2自受体.更多相关视频
06:36A Decentralized Ex Vivo Murine Bladder Model with the Detrusor Muscle Removed for Direct Access to the Suburothelium during Bladder Filling
Published on: November 28, 2019
7.3K
09:17In Vivo Luminal Measurement of Distension-Evoked Urothelial ATP Release in Rodents
Published on: September 7, 2022
1.7K
相关概念视频
01:31Adrenergic Receptors: ɑ Subtype
2.1K
Adrenoceptors are classified into α and ꞵ classes based on their potencies to catecholamine agonists. α-adrenoceptors show the following order of catecholamine potency:
Adrenaline ≥ Noradrenaline >> Isoprenaline
α-adrenoceptors are further divided into α1 and α2-adrenoceptors.
α1-Adrenoceptors: These receptors are located postsynaptically on the effector organs and cause constriction of smooth muscle mediated by activation of phospholipase...
Adrenaline ≥ Noradrenaline >> Isoprenaline
α-adrenoceptors are further divided into α1 and α2-adrenoceptors.
α1-Adrenoceptors: These receptors are located postsynaptically on the effector organs and cause constriction of smooth muscle mediated by activation of phospholipase...
2.1K
01:22Adrenergic Antagonists: Pharmacological Actions of ɑ-Receptor Blockers
1.0K
α-Adrenergic antagonists, known as α-blockers, exert their effects by inhibiting α-adrenoceptors, leading to specific physiological actions. α1-blockers and α2-blockers have distinct pharmacological actions and therapeutic applications.
α1-blockers: These drugs inhibit α1-adrenoceptors on smooth muscle cells, resulting in vasodilation. This vasodilation lowers blood pressure, making α1-blockers valuable in treating hypertension. Additionally,...
α1-blockers: These drugs inhibit α1-adrenoceptors on smooth muscle cells, resulting in vasodilation. This vasodilation lowers blood pressure, making α1-blockers valuable in treating hypertension. Additionally,...
1.0K
01:30Ligand-Gated Ion Channel Receptor: Gating Mechanism
2.7K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
2.7K
01:21Drugs Affecting Neurotransmitter Release or Uptake
1.2K
Certain drugs can affect how neurotransmitters called catecholamines, are released or taken back up in the adrenergic neuron. They can have different effects on the body's sympathetic transmission. Reserpine, a natural compound found in the Rauwolfia shrub, blocks a transporter called vesicular monoamine transporter (VMAT), which leads to a buildup of catecholamines in the cell and reduces sympathetic transmission. Another drug called guanethidine works in multiple ways, including blocking...
1.2K
01:17Adrenergic Antagonists: Chemistry and Classification of ɑ-Receptor Blockers
1.1K
Adrenergic antagonists, or sympatholytics, inhibit adrenoceptor activation driven by catecholamines or agonists. Based on their adrenoceptor specificity, adrenergic blockers can be categorized into two primary groups: α-adrenergic blockers (α-blockers) and β-adrenergic blockers (β-blockers). α-blockers interact with α1 and α2 subtypes of α-adrenoceptors.
Nonselective α-blockers: Nonselective α-blockers contain haloalkylamine or imidazoline...
Nonselective α-blockers: Nonselective α-blockers contain haloalkylamine or imidazoline...
1.1K
01:30Urinary Tract Calculi III: Medical Management
32
The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
32