针对mopox的MBA-VN疫苗的真实有效性,这是一个测试负的病例控制研究
Pía Escobar-Ziede1, Blanca Borras-Bermejo2, Laia Pinós-Tella1
1Servei de Medicina Preventiva i Epidemiologia, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain; Grup de recerca d'Epidemiologia i Salut Pública, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.
Vaccine
|May 28, 2025
概括
在真实世界中,MVA-BN疫苗对mopox的有效性是通过测试负的研究来估计的. 调整后的疫苗有效率达到了74%,但考虑到流行病学周,其有效率降至44%.
科学领域:
- 传染性疾病 传染性疾病
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- 2022年Mpox (病毒性疾病) 爆发导致MVA-BN疫苗获得授权.
- 尽管免疫性很高,但对MVA-BN疫苗的有效性 (VE) 存在有限的现实世界的证据.
- 该研究重点关注在巴塞罗那一家三级医院测试的成年人中出现症状的mopox.
研究的目的:
- 为了估计至少一个MVA-BN疫苗剂量对症状的mpox.的真实世界VE.
- 评估2022年7月至2023年12月期间对成人进行mopox测试的VE.
主要方法:
- 试验负的病例控制研究设计.
- 包括通过PCR测试mopox的成年人 (病例:PCR阳性,对照:PCR阴性).
- 使用多变量逻辑回归计算 VE: (1 - 调整的赔率比) × 100%.
主要成果:
- 301名参与者:126个病例,175个对照组.
- 原始VE (≥1剂量≥14天前) 为47%.
- 调整 VE: 74% (性别,年龄,中心,性病史,风险标准); 44% (额外调整为流行病学周).
- 在具有mopox风险标准的男性中观察到类似的模式.
结论:
- 提供特定于背景的,真实世界的VE数据,用于单剂量MVA-BN疫苗对抗症状的mpox.
- 根据调整策略,VE估计有很大的差异.
- 强调必须考虑流行病学周,以防止对mopox VE的高估.
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