儿童急性尾炎:两个与临床指标和严重程度相关的微生物状态
Ziyu Liu1, Keqiang Yan2, Jing Li3
1Tianjin Medical University, Tianjin 300070, China; Precision Medicine Laboratory, Precision Medicine Center, Tianjin Children's Hospital, Children's Hospital, Tianjin University, Tianjin 300134, China.
Diagnostic microbiology and infectious disease
|May 28, 2025
概括
这项研究揭示了明显的微生物特征和血清生物标志物,区分了儿童的简单和复杂的急性尾炎. 这些发现突显了微生物组在尾炎严重程度和发病过程中的作用.
科学领域:
- 微生物学 微生物学
- 儿科手术 儿科手术
- 胃肠病学 胃肠病学
背景情况:
- 急性尾炎是一种常见的手术紧急情况,原因不明.
- 尾炎在临床上被分为简单尾炎 (SA) 和复杂尾炎 (CA).
- 微生物失生症与尾炎的发病有关.
研究的目的:
- 描述小儿尾炎的微生物组成和功能.
- 为了确定与尾炎严重程度相关的微生物和血清生物标志物.
- 探索尾炎中微生物群和临床参数之间的关系.
主要方法:
- 从尾切除病例 (3-15岁) 收集了74个儿科腹内样.
- 根据病理学分类样本为SA (n=27) 和CA (n=47).
- 用于微生物分析和评估临床参数的metagenomic分析.
主要成果:
- 在SA组中,Burkholderia,Mycobacterium和Klebsiella的水平较高.
- 在CA组中,Porphyromonas,Bacteroides,Fusobacterium,Prevotella和Tannerella的数量有所增加.
- 血清生物标志物 (CRP,PCT等) 的显著差异 并观察到微生物代谢/抗生素耐药性.
结论:
- 鉴定出独特的微生物和血清生物标志物,用于不同严重程度的急性尾炎.
- 突出了微生物组在尾炎的病因和发病过程中的关键作用.
- 展示了微生物群落与宿主炎症反应之间的复杂相互作用.
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