乳酸酸通过CD40LG下调和SOCS3介导的JAK1/STAT3通路抑制来抑制败血症中的T细胞激活

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Hui Zhang1, Fanbing Meng1, Jinxuan Tang1

  • 1Department of Anesthesiology and Perioperative Medicine, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China.

Biochimica et biophysica acta. Molecular basis of disease
|May 28, 2025
PubMed
概括

败血症中乳酸盐水平升高通过降低CD40LG和SOCS3的调节来抑制T细胞活化,影响激酶活性和免疫细胞功能. 这项研究确定了参与乳酸诱导免疫抑制的关键基因.

关键词:
在CD40LG中,CD40LG是CD40LG.乳酸盐是一种乳酸盐.淋巴细胞 淋巴细胞在 SOCS3 中,SOCS3 是 SOCS3 的代名词.败血症 这是一种败血症.

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