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在斑马鱼胚胎中评估bongkrekic酸的毒性

Jiun-Lin Horng1, Kuan-Yi Lee2, Jen-Leih Wu3

  • 1Department of Anatomy and Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP
|May 28, 2025
PubMed
概括

邦克雷克酸 (BA) 在斑马鱼胚胎中引起严重的发育毒性,导致器官损伤和功能障碍. 这项研究突出了BABA的重点.

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...