功能视力测试作为眼科临床试验结果测量:一个范围审查
Shabnam Raji1,2, Arun James Thirunavukarasu3,4, Laura Jayne Taylor3,2
1Nuffield Laboratory of Ophthalmology, Department of Clinical Neurosciences, University of Oxford, Oxford, UK shabnam.raji@ndcn.ox.ac.uk.
BMJ open
|May 28, 2025
概括
本综述确定了用于眼科临床试验的功能视觉测试. 主要障碍包括可访问性和验证性,阻碍它们的广泛采用.
科学领域:
- 眼科医生 眼科 眼科
- 临床试验 临床试验
- 视觉科学科学 视觉科学
背景情况:
- 功能性视力测试对于评估眼科中以患者为中心的结果至关重要.
- 目前的测试在验证和可访问性方面存在差异,这影响了它们在临床试验中的使用.
研究的目的:
- 为了确定可用的功能视觉测试.
- 评估它们作为临床试验的适用性眼科的临床试验结果措施.
主要方法:
- 根据PRISMA-ScR指南进行了全面的范围审查.
- 文学搜索包括MEDLINE,Embase和从2003年到2024年的灰色文学.
- 两位独立审稿人对文章进行了选,以评估眼科疾病中的功能视力.
主要成果:
- 从包括的73个文章中,确定了45个独特的功能视觉测试.
- 82%的测试显示了统计验证,外围视网膜疾病是最受研究的.
- 障碍物课程和视觉搜索测试显示出希望,虚拟现实和眼睛跟踪替代品正在开发中.
结论:
- 功能视觉测试可以指导患者优先考虑的眼科治疗的发展.
- 收养障碍包括有限的可访问性,不足的验证和早期发展阶段.
- 本综述为评估眼科临床试验的功能视觉测试提供了一个参考.
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