确定长期疾病的成年人实地行走试验的最小重要差异:系统性审查和元分析
Enya Daynes1,2, Ruth E Barker3,4,5, Amy V Jones1
1Centre of Exercise and Rehabilitation Sciences, Leicester NIHR Biomedical Research Centre-Respiratory, University Hospitals of Leicester NHS Trust, Leicester, UK.
概括
这项研究确定了长期疾病的成年人进行6分钟步行距离 (6MWD),增量穿步行测试 (ISWT) 和耐力穿步行测试 (ESWT) 的新最小重要差异 (MID). 这些MID有助于解释运动干预结果,并优化临床试验设计.
科学领域:
- 康复医学 康复医学 康复医学
- 临床运动生理学 临床运动生理学
- 健康 结果 研究 研究 结果
背景情况:
- 在实地行走测试中解释变化的临床意义是具有挑战性的,因为异质的最小重要差异 (MID).
- 建立标准化的MID对于在长期条件下对干预措施的一致评估至关重要.
研究的目的:
- 为了确定6分钟步行距离 (6MWD),增量穿步行测试 (ISWT) 和耐力穿步行测试 (ESWT) 的最小重要差异 (MID).
- 为患有长期疾病的成年人提供可靠的MID,特别关注运动干预.
主要方法:
- 对使用基于的方法来生成6MWD,ISWT和ESWT的MIDs的研究进行了系统审查.
- 分析了42项涉及13,949名参与者的研究数据,重点关注12项涉及炼干预措施的研究.
主要成果:
- 建立了聚合的MID:26m (22-40m) 为6MWD和53m (44-62m) 为ISWT在各种条件的运动干预中.
- 针对不同的疾病确定了特定的MID:6MWD (25m呼吸,23m心脏,37m神经/肌肉骨),ISWT (48m呼吸,70m心脏) 和ESWT (159s在COPD中).
- 异质性是合理的 (I2=48%用于6MWD,I2=47%用于ISWT).
结论:
- 为6MWD,ISWT和ESWT在长期疾病的运动干预中提出了新的基MID.
- 这些MID可以在全球范围内用于元分析,优化样本大小计算和临床服务的基准测试.
- 标准化的MID提高了研究结果和临床实践的一致性和可比性.
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