与代谢功能障碍相关的脂肪性肝病 (MASLD). 评估代谢功能障碍,心血管风险因素和生活习惯
Hala Abdallah1, Mohamad Khalil1, Ewa Awada1
1Clinica Medica "A. Murri" and Department of Precision and Regenerative Medicine and Ionian area (DiMePre-J), University of Bari "Aldo Moro", Bari, Italy.
European journal of internal medicine
|May 28, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 与心血管风险有关. 腰围是一个关键指标,TyG指数可以帮助预测MASLD患者的风险.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 代谢综合征是代谢综合征的一种.
背景情况:
- 脂肪性肝病 (SLD) 是代谢功能障碍的标志物,与动脉样硬化心血管疾病 (ASCVD) 密切相关.
- 该研究将SLD重新归类为新代谢功能障碍相关的脂肪性肝病 (MASLD) 框架.
- 研究了SLD的代谢失调患者的性别差异,代谢风险因素和生活方式.
研究的目的:
- 调查SLD患者代谢风险因素和生活习惯中的性别差异.
- 在MASLD框架下分类的患者中分析心血管风险.
- 在MASLD患者中确定ASCVD风险分层的关键指标.
主要方法:
- 从心脏代谢诊所招募了400名患者进行临床评估,人体测量和实验室分析.
- 评估生活方式因素,包括遵守地中海饮食 (MD) 和身体活动.
- 使用超声波来评估肝硬化和带斑块;将患者分为MASLD或MetALD组.
主要成果:
- SLD是普遍存在的 (65.5%),主要是作为 MASLD (93.9%). 男性的SLD患病率和风险因素较高.
- 在MetALD患者中,ASCVD风险和斑块发病率较高,尽管具有相似的失代代谢特征.
- 腰围与ASCVD风险相关;TyG指数显示,在选择的MASLD患者中,对ASCVD风险预测有希望.
结论:
- 在MASLD中,全面的表型化对于准确的心血管风险分层至关重要.
- 腰围是SLD患者ASCVD的重要风险指标.
- 泰格指数可能是预测特定SLD群体中ASCVD风险的有价值工具.
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