MOF涂层提高了微电机的离子耐受性
Leyan Ou1, Kunfeng Liu1, Yifan Zhang2
1College of Chemistry and Materials Science, Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry, Jinan University, Guangzhou, Guangdong, 510632, P.R. China.
Angewandte Chemie (International ed. in English)
|May 28, 2025
概括
用ZIF-8 MOF支架涂层微/纳米发动机可以在高盐生物医学环境中进行推进. 这一突破提高了离子耐受性,并为向药物输送应用开辟了新的途径.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
- 生物医学工程 生物医学工程
背景情况:
- 电驱动的微/纳米电机 (EMNM) 在生物医学应用方面表现有前途,但由于离子火,在高盐条件下扎.
- 盐水环境中的电气双层破坏限制了传统EMNMs的有效性.
研究的目的:
- 为生物医学应用开发一种提高EMNMs盐分耐受性的多功能策略.
- 研究ZIF-8金属有机框架 (MOF) 涂层的使用,以便在高盐溶液中实现EMNM推进.
主要方法:
- 使用异质生长过程,用ZIF-8涂层微电机.
- 优化MOF层厚度和微电机几何,以提高性能.
- 在酸盐缓冲盐水 (PBS) 和模拟生物环境中测试微运动运动和离子耐受性.
主要成果:
- 与没有涂层的同行相比,涂有ZIF-8的微型电机显示出显著增强的离子耐受性,提高了EI50的266倍.
- 微电机在PBS和980nm NIR光下实现了稳定,可控制的运动,即使通过模拟的生物组织.
- ZIF-8涂层提供了药物载荷能力与pH响应释放,并表现出生物相容性.
结论:
- ZIF-8 MOF涂层是一种可扩展和多功能策略,可以克服EMNM中盐引起的限制.
- 这些增强的EMNM适用于在生理条件下的向药物输送和其他生物医学应用.
- 开发的MOF涂层方法扩大了EMNM在复杂的生物环境中的潜力.
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