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Updated: Sep 20, 2025

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
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一个RNA转甲基化途径控制脏的原潜力

Harini Ramalingam1, Jesus Alvarez1, Andrea Flaten1

  • 1Department of Internal Medicine and Division of Nephrology, UT Southwestern Medical Center, Dallas, TX, 75390, USA.

Nature communications
|May 28, 2025
PubMed
概括

脏发育依赖于甲胺代谢. 通过METTL3增强S-adenosylmethionine (SAM) 和RNA转甲基化,增强脏前体细胞和脏形成,为脏疾病提供新的治疗点.

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