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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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针对BCL-XL的BH3模拟剂在具有RB1损失和复制应激反应的固体瘤中具有有效性

Andreas Varkaris1,2, Keshan Wang1,3, Mannan Nouri1

  • 1Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Nature communications
|May 28, 2025
PubMed
概括

在固体瘤中,BH3模仿剂的疗效有限. 然而,缺乏RB1的瘤和受复制压力的瘤对BCL-XL抑制很敏感,这表明了新的治疗策略.

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