在出生时体重非常低的早产成年人中视觉通路功能:两国出生队列研究
Anna P M Jørgensen1, Maarit Kulmala2,3, Dordi Austeng4,5
1Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology (NTNU), 7491, Trondheim, Norway. anna.p.m.jorgensen@ntnu.no.
Documenta ophthalmologica. Advances in ophthalmology
|May 28, 2025
概括
过早出生且出生体重非常低 (VLBW) 的成年人表现出微妙的视觉路径差异,包括皮质反应延迟和斑点功能改变. 这些电生理学变化没有影响最佳校正视敏度 (BCVA).
科学领域:
- 眼科医生 眼科 眼科
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
背景情况:
- 非常低出生体重 (VLBW) 的早产是不良神经发育结果的重要危险因素.
- 视觉通路的发展可能会受到早产和低出生体重的影响,可能导致长期的功能缺陷.
- 了解出生于VLBW的成年人的长期视觉功能对于识别潜在的健康风险和指导干预至关重要.
研究的目的:
- 为了研究早产与非常低出生体重 (VLBW) 在成年期对黄斑和视觉通路功能的长期影响.
- 为了确定最佳校正视敏度 (BCVA) 是否与出生于VLBW的成年人的电生理学反应有关.
- 为了比较早产成人与VLBW之间的视觉通路功能,以及出生后的对照.
主要方法:
- 在芬兰和挪威的纵向研究中,从芬兰和挪威的纵向研究中招募了50名患有VLBW的早产成年人和77名终产对照 (31-41岁).
- 进行模式逆转电网红图 (PR-ERG) 和视觉唤起潜能 (PR-VEP) 来评估黄斑和视觉通路功能.
- 分析了关键的电生理成分 (如P50,N95,N75,P100,N145) 和BCVA,并在VLBW和对照组之间进行了比较.
主要成果:
- 与对照组相比,患有VLBW的早产成年人表现出明显更长的N145峰值时间 (表明皮质处理延迟).
- 在PR-ERG中,VLBW组的N95:P50幅度比也较低,这表明黄斑功能可能发生变化.
- 尽管存在这些电生理学差异,但BCVA在两组中都是正常的和相似的,在电生理学反应和BCVA之间没有发现显著的关联.
结论:
- 虽然初级视觉皮层反应 (N75,P100) 是可比的,但在较高的皮层水平 (N145) 和黄斑功能 (质细胞反应) 中,在早产VLBW的成年人中观察到微妙的电生理学偏差.
- 这些发现表明,VLBW的早产可能导致亚临床视觉路径变化,而这些变化不会在成年时表现为视力敏度降低.
- 需要进一步的研究来了解这些微妙的视觉通路差异的临床影响和潜在的长期后果.
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