饮食中使用葡萄糖胺补充剂和降低炎症性肠病患者的手术风险:一项前性队列研究
Jiawei Geng1,2, Xuejie Chen1, Sidan Wang1
1Department of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
常见的补充剂葡萄糖胺的使用与炎症性肠病 (IBD) 相关手术的风险降低有关. 这一发现表明,葡萄糖胺可能是管理IBD的有益策略.
科学领域:
- 胃肠病学 胃肠病学
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 炎症性肠病 (IBD) 包括克罗恩氏病和性结肠炎,通常需要手术干预.
- 葡萄糖胺是一种受欢迎的食补充剂,具有潜在的抗炎性质.
- 葡萄糖胺对IBD相关手术结果的影响仍在调查中.
研究的目的:
- 调查葡萄糖胺补充剂与IBD相关手术风险之间的关联.
- 为了确定葡萄糖胺的使用是否会影响IBD患者的手术结果.
主要方法:
- 一项前性队列研究,利用英国生物库从6059名IBD患者的数据.
- 通过自我报告,饮食回忆和初级保健处方数据来评估葡萄糖胺的使用情况.
- 从住院病例记录中确定了IBD相关的手术;统计分析采用了Cox比例风险和后勤回归模型.
主要成果:
- 在平均12.2年的随访期间,发生了684次IBD相关的手术.
- 习惯性使用葡萄糖胺的人显示IBD相关手术的风险明显降低 (HR 0.73,P=0.009),特别是在克罗恩病 (HR 0.60,P=0.011).
- 与非使用者相比,偶尔和持续使用者的手术风险降低;较高的处方葡萄糖胺剂量与较低的手术风险相关 (OR 0.15,P=0.034).
结论:
- 葡萄糖胺补充剂与IBD相关手术风险降低有关.
- 这些发现表明,葡萄糖胺可能是IBD管理的安全和有前途的辅助策略.
- 进一步的研究可以探索最佳剂量和特定患者群体在IBD中使用葡萄糖胺.
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