在儿童中用于医疗目的的大麻素:一个活生生的系统性审查
Manik Chhabra1, Arun Paul1, Omaymah Abulannaz1,2
1Department of Pharmacology and Therapeutics, Max Rady College of Medicine, University of Manitoba, Winnipeg, Canada.
Acta paediatrica (Oslo, Norway : 1992)
|May 29, 2025
概括
这个活生生的系统性审查绘制了医疗大麻素对儿童的安全性和益处. 纯化大麻 (CBD) 显得有望减少发作,尽管常见的副作用包括昏昏欲睡和食欲下降.
科学领域:
- 儿科药理学 儿科药理学
- 系统性审查和元分析.
- 大麻素治疗疗法.
背景情况:
- 基于大麻素的药物越来越多地被用于儿童疾病.
- 对儿童的安全性和疗效的全面数据对于临床实践至关重要.
- 由于不断变化的研究环境,需要不断更新的证据库.
研究的目的:
- 建立一个活生生的系统性审查 (LSR) 以持续评估医用大麻素在儿童群体中使用的安全性和益处数据.
- 综合来自各种研究设计的证据,包括干预性,观察性,调查性和定性研究.
- 识别知识缺口,并为儿童大麻素治疗的未来研究方向提供信息.
主要方法:
- 搜索了主要的生物医学数据库 (MEDLINE,Embase,PsycInfo,Cochrane图书馆) 从创立到2023年4月.
- 包括涉及18岁以下参与者接受用于医疗条件的植物性或制药性大麻素的研究.
- 提取并分析了关于研究设计,适应症,大麻素类型,剂量,疗效结果和不良事件的数据.
主要成果:
- 包括来自37,189个引用的276项研究,重点关注耐火性,癌症和自闭症谱系障碍.
- 纯化大麻 (CBD) 是干预研究中最常见的大麻素,随机对照试验中记录下了发作减少 (30-50%).
- 在儿科研究中报告的常见不良事件包括昏昏欲睡,腹,吐和食欲下降.
结论:
- 活体系统性审查提供了持续更新的关于儿童大麻素使用的证据基础.
- 这些发现突出了纯化大麻 (CBD) 对等特定儿科疾病的潜力.
- 持续更新将指导临床实践,并确定儿童大麻素治疗方法未来研究的关键领域.
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