在患有不同指数发现的患者的结肠镜检查后发生超慢性晚期新生病的风险
Kai Song1,2, Shengyu Zhang1,2, Jiahui Luo3,4
1Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
这项研究在中国人群中结肠镜检查后确定了甲时晚期瘤 (AN) 的关键风险因素. 了解这些因素可以实现个性化的风险分层和优化监测间隔.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 接受结肠镜检查的患者面临发展甲时晚期瘤 (AN) 的风险.
- 准确的风险分层对于确定适当的监测间隔至关重要.
- 索引结肠镜检查结果显著影响未来AN的风险.
研究的目的:
- 探索与甲时性AN相关的风险因素.
- 根据不同的指数结肠镜检查结果,完善风险分层策略.
- 为结肠镜患者提供个性化监测协议的信息.
主要方法:
- 在中国 (2012-2023) 进行多次结肠镜检查的3638名患者的回顾性队列研究.
- 考克斯回归分析调整了共变量以估计AN风险.
- 卡普兰-梅尔对累积危险和敏感性分析的估计.
主要成果:
- 在非晚期腺瘤组中,近端腺瘤,腺瘤≥6mm和≥3腺瘤增加了AN风险.
- 在非显著发现组中,年龄≥50岁,家族CRC病史和男性性别增加了AN风险.
- 患有已确定的风险因素的患者更早达到AN的参考风险.
结论:
- 在中国人群中,在不同基线诊断子组中确定了超慢性AN的独立风险因素.
- 通过考虑这些已识别的风险因素,可以促进个性化风险分层.
- 风险概况对于确定最佳结肠镜监测间隔至关重要.
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