饮食对前列腺癌免疫疗法的影响
Loan D Duong1,2, Xin Lu1,2,3
1Department of Biological Sciences, Boler-Parseghian Center for Rare Diseases, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.
Immunotherapy
|May 29, 2025
概括
饮食干预可以重新编程前列腺癌中的免疫抑制瘤微环境,提高免疫治疗的有效性. 本综述探讨了性饮食和其他化合物如何改善癌症免疫力和治疗结果.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 晚期前列腺癌的治疗选择有限,预后不佳.
- 前列腺瘤通常具有"冷"的微环境,阻碍免疫治疗的有效性.
- 饮食干预正在成为调节瘤微环境的策略.
研究的目的:
- 审查和整合关于饮食调节前列腺癌免疫力的发现.
- 探索增强免疫疗法与饮食策略的机制性见解.
- 建议潜在的组合疗法,包括饮食和免疫治疗.
主要方法:
- 临床前和早期临床研究的文献综述.
- 综合最近关于饮食干预和前列腺癌免疫力的研究结果.
- 专注于对饮食与瘤微环境相互作用的机制性理解.
主要成果:
- 性饮食,氨酸限制和提取物可以改变瘤微环境.
- 像β-基酸盐这样的饮食衍生因素显示出直接的抗瘤免疫效应.
- 饮食干预措施在增强免疫疗法反应方面表现有前途.
结论:
- 饮食调节提供了一种有希望的方法来克服前列腺癌中免疫疗法耐药性的方法.
- 将饮食干预与免疫疗法结合起来,可能是一个新的治疗策略.
- 需要进一步的翻译研究来优化这些组合方法.
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