超越荷尔蒙:在绝经后妇女的阴道微生物群动态3PM方法
Panchita Pongsupasamit1, Chanisa Thonusin2,3,4, Suchaya Luewan5
1Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
The EPMA journal
|May 29, 2025
概括
更年期改变阴道微生物群,变化如减少乳酸菌的优势可能预测更年期状态和症状. 使用这些生物标志物的个性化医疗方法可以改善阴道健康.
科学领域:
- 妇科医学 妇科医学
- 微生物组研究的研究.
- 个性化医疗是个性化的医疗.
背景情况:
- 更年期涉及雌激素的下降,导致血管运动和泌尿生殖系统症状.
- 阴道微生物群在更年期期间发生显著的变化,影响更年期的生殖泌尿综合征 (GSM) 严重程度.
研究的目的:
- 用预测,预防和个性化医学 (PPPM / 3PM) 审查绝经后妇女的阴道微生物群动态.
- 确定微生物群的变化作为更年期状态的预测生物标志物,过早的卵巢衰竭和GSM.
- 评估阴道失生症的风险分层和治疗策略.
主要方法:
- 综合文献综述,重点关注PPPM/3PM原则.
- 在更年期期间分析阴道微生物群组成的特征性变化.
- 评估用于微生物群正常化的激素和非激素干预措施.
主要成果:
- 更年期与增加的α多样性和减少Lactobacillus在阴道微生物群中的占主导地位有关.
- 这些变化可以作为更年期状态和GSM的预测生物标志物.
- 激素和非激素治疗都可以使阴道微生物群正常化并改善健康.
结论:
- PPPM/3PM将更年期护理转变为使用微生物群生物标志物的积极主动,精确的策略.
- 需要进一步的研究来验证预测生物标志物和标准化查协议.
- 个性化,针对微生物群的干预措施对于改善绝经后妇女的生活质量至关重要.
相关概念视频
Surface Membrane Barriers
1.5K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
1.5K
Vagina
10.8K
The vaginal canal is a tubular structure averaging about 10 cm in length that acts as the entryway to the female reproductive system and the passageway for menstrual flow and childbirth. The interior walls of the vagina exhibit concentric folds called rugae and are topped by an area known as the fornix, which connects with the protruding cervical portion of the uterus. This canal is comprised of an external fibrous layer, a muscular middle layer, and an inner lining with mucosal rugae, which...
10.8K
Hormonal Regulation of the Menstrual Cycle
729
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
729
Anatomy of the Intestines
74.3K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
74.3K


