组织扩展器的存在不会影响放射治疗剂量分布到心脏和肺部
Jeewon Chon1, Peter Laub2, Mike Wesolowski1
1From the Loyola University Stritch School of Medicine, Maywood, IL.
Plastic and reconstructive surgery. Global open
|May 29, 2025
概括
乳腺癌治疗中使用的组织扩展剂 (TE) 不会影响到心脏或肺部的辐射剂量. 然而,在接受乳腺切除术后放射治疗 (PMRT) 的患者中,较高的体重指数 (BMI) 与心脏辐射剂量增加有关.
科学领域:
- 在瘤学瘤学.
- 放射疗法是一种放射治疗.
- 医学物理 医学物理
背景情况:
- 乳腺切除术后的放射治疗 (PMRT) 越来越多地用于乳腺癌患者,特别是节点阳性病例.
- 虽然已知PMRT对重建乳房的风险,但使用组织扩展器 (TEs) 时对心脏和肺部等附近器官的影响尚不清楚.
研究的目的:
- 调查TEs在PMRT期间对心脏和肺部辐射剂量分配的影响.
- 探索TE填充体积和风险器官的辐射剂量之间的相关性.
- 分析身体质量指数 (BMI) 和心脏辐射剂量之间的关系.
主要方法:
- 对124名经过乳房切除和PMRT3DCT规划的患者进行了回顾性分析.
- 仅进行乳腺切除和与TE组进行乳腺切除之间的异侧肺和心脏的辐射剂量统计数据的比较.
- 基于TE手术内填充体积的剂量统计数据分析 (≤60毫升 vs. >60毫升).
- 剂量统计和患者的BMI之间的相关性分析.
主要成果:
- 在患有和没有TE的患者之间,没有观察到肺部或心脏辐射剂量的显著差异.
- TE填充体积没有显著影响到肺部或心脏的辐射剂量指标.
- 在BMI和最大心脏辐射剂量 (P=0.03) 之间发现了显著的正相关性.
结论:
- 在PMRT期间,TEs的存在和它们的填充体积不会改变辐射剂量分布到心脏和肺部.
- 在接受PMRT的患者中,增加的BMI与心脏的最大辐射剂量更高有关.
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