系统性狼红斑血临床试验中不公平的人口代表性的系统性审查
Seth Sims1, Kaylyn Rowsey1, Christian Hemmerich1
1Oklahoma State University Center for Health Sciences, Tulsa.
Arthritis care & research
|May 29, 2025
概括
美国的系统性红斑狼 (SLE) 临床试验显示,黑人,亚洲人和西班牙裔人口的代表性很差,没有包括老年人. 需要策略来提高SLE研究的多样性,以更好地标准化治疗.
科学领域:
- 免疫学和自身免疫性疾病
- 临床试验多样性 临床试验多样性
- 健康差异 在健康上的差异
背景情况:
- 系统性红斑狼 (SLE) 不成比例地影响历史上边缘化的人群,死亡率更高.
- 准确的临床试验代表对于有效评估SLE治疗至关重要.
- 美国目前的SLE临床试验缺乏足够的多样性,限制了概括性.
研究的目的:
- 评估历史上被边缘化的人群在美国SLE临床试验中的参与.
- 为了确定SLE临床试验参与者数据中的人口差距.
主要方法:
- 2018-2023年间发表的美国SLE临床试验的系统综述和元分析.
- 从18个试验中提取参与者的性别,年龄,种族和民族数据.
- 由两个审查员进行独立选和数据提取.
主要成果:
- 18个美国SLE临床试验被分析为人口代表性.
- 性别和性别代表性充足,但在61.1%的研究中,种族和民族多样性很差.
- 发现黑人,亚裔和西班牙裔参与者的代表性明显不足;老年人明显缺席.
结论:
- 美国SLE临床试验显示了显著的种族和民族差异,白人参与者过度代表.
- 迫切需要制定战略,以加强黑人,亚裔,西班牙裔和老年人的纳入SLE研究.
- 提高SLE试验的多样性对于治疗标准化和研究相关性至关重要.
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