2型糖尿病减轻了逆行附带流,并在缺血性中风后促进白细胞粘附
Yoshimichi Sato1,2,3, Yuya Kato1,2,3, Atsushi Kanoke1,2,3
1Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
概括
2型糖尿病甚至在中风之前就会损害血液流动和血管功能. 在糖尿病小鼠中,中风会导致更严重的血流缺陷和炎症增加,导致恢复较差.
科学领域:
- 神经科学是一个神经科学.
- 心血管科学 心血管科学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 2型糖尿病 (T2DM) 与中风的不良结果有关.
- 在T2DM中,勒普托门关节的附带补偿受损.
- 脑卒中后的中性粒细胞活动可以降低血液流动速度.
研究的目的:
- 定义中风后T2DM中担保流通的时间和空间变化.
- 为了研究T2DM小鼠的血流动力学和血管直径变化.
- 在T2DM中评估白细胞-内皮质粘附和中风后的炎症.
主要方法:
- 在清醒控制和T2DM小鼠中使用了双光子显微镜.
- 监测血管动脉和静脉,血液流动速度和血管直径.
- 量化白细胞-内皮粘附和中性粒细胞透中脑动脉 (MCA) 中风后.
主要成果:
- T2DM小鼠在中风前表现出较小的血管和减少的流速.
- 在中风后,T2DM小鼠表现出动脉和静脉血流持续减少.
- 在中风后的T2DM小鼠中,白细胞粘附和中性粒细胞透率升高.
结论:
- T2DM导致先前存在的血管缺陷和中风后血液动力学受损.
- 在T2DM中增加的炎症和血管重塑有助于中风的不良结果.
- 这些发现凸显了T2DM作为中风严重程度的重要风险因素.
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