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Updated: Jun 13, 2025

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用高斯加速分子动力学探测的酸化媒介对联结BACE1的构造动态的影响的分子机制

Chaoyue Jia1, Yanqi Sun1, Jianzhong Chen2

  • 1School of Physics and Electronics, Shandong Normal University, Jinan, 250358, China. liuxinguo@sdnu.edu.cn.

Physical chemistry chemical physics : PCCP
|May 29, 2025
PubMed
概括

在T259的酸化改变了β-分泌酶1 (BACE1) 的结构,影响其与抑制剂的相互作用. 这一发现对于开发有效的阿尔茨海默病 (AD) 治疗方法至关重要.

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