胸腔血管移植感染保守治疗的结果
Mathias Van Hemelrijck1, Juri Sromicki1, Petar Risteski1
1Department of Cardiac Surgery, University Hospital Zurich, Zurich, Switzerland.
概括
对于胸部血管移植感染,一种保守的仅用抗生素的策略显示,在选定的不可手术的患者中,存活率为82.9%. 这种方法为大动脉移植感染提供了一种有价值的治疗选择,当手术不可行时.
科学领域:
- 心血管外科心血管外科
- 传染性疾病 传染性疾病
- 血管外科 血管外科
背景情况:
- 胸腔血管移植感染是大动脉手术后的严重并发症,死亡率高.
- 标准治疗包括手术和抗生素,但不可手术的患者需要替代策略.
- 这些感染的非手术抗微生物治疗结果有限.
研究的目的:
- 为了评估患者的特征和仅抗生素治疗胸部血管移植感染的抗生素策略的结果.
- 评估在不适合进行重复手术的患者中保守治疗的疗效.
- 描述抗微生物治疗的结果,而不是广泛的脱bridement.
主要方法:
- 来自第三级中心的潜在队列的回顾性分析.
- 患者基线特征的描述性统计.
- 卡普兰-梅尔生存分析.
主要成果:
- 在2012年11月至2022年12月期间,66名患有大动脉移植感染的患者被确定.
- 44名患者接受了仅抗生素策略或选择性除菌的抗生素.
- 随访时间中位数为4.8年,累计存活率为82.9%; Streptococcus spp. 是最常见的病原体.
结论:
- 使用抗生素单独或有选择性除菌的保守方法可以在选定的患者中获得可接受的结果.
- 这一策略代表了潜在的有价值的治疗选择,胸部血管移植感染的患者,谁不是手术的候选人.
- 进一步的研究可以探索为这个患者群体优化抗生素治疗方案.
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