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mRNA COVID-19 疫苗接种和疹之间的关联:丹麦全国基于登记册的队列研究

Elena Dudukina¹, Elvira V Brâuner¹, Cæcilie B Christiansen¹

¹The Data Analytics Centre, Danish Medicines Agency, Copenhagen S, Denmark.

Scandinavian journal of public health

|May 29, 2025

概括

莫德纳 (MOD) 的mRNA COVID-19疫苗与疹,特别是慢性疹的风险增加有关. 瑞生物科技 (Pfizer-BioNTech,简称BNT) 疫苗没有显示出疹的风险增加.

科学领域:

免疫学免疫学免疫学
疫苗学疫苗学疫苗学
皮肤病学皮肤病学

背景情况:

包括Comirnaty (Pfizer-BioNTech, BNT) 和Spikevax (Moderna, MOD) 在内的mRNA COVID-19疫苗已被广泛使用.
疹是一种常见的皮肤疾病,其特点是出疹和胀.

研究的目的:

研究mRNACOVID-19疫苗接种与患疹的风险之间的关联.
为了比较BNT和MOD疫苗接种后的疹风险.

主要方法:

通过使用丹麦医疗保健登记册进行了一项全国性的观察队列研究.
接种mRNACOVID-19疫苗的4,700,301人与大流行前一般人口中的5,480,146人进行了比较.
对参与者进行了病诊断的跟踪,使用大流行前数据标准化了发病率.

主要成果:

在所有疫苗序列中,慢性疹的整体标准化发病率 (SIR) 为0.83 (95% CI 0.71-0.96),其他类型的疹为1.14 (95% CI 1.03-1.25) 观察到.
遵守MOD疫苗接种计划与慢性 (SIR 3.00) 和其他类型的疹 (SIR 3.65) 的风险增加了3到4倍.
敏感性分析证实MOD疫苗序列后风险增加了四倍,但BNT序列没有.

结论:

现代 (MOD) 疫苗接种计划与慢性和其他类型的疹的发生率高于预期.
在Pfizer-BioNTech (BNT) 疫苗接种计划和疹风险增加之间没有发现任何关联.

关键词:

mRNA COVID-19 疫苗的使用情况疹病是一种疹病.

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