达丁类药物使用与骨密度之间的截面和纵向关联:曼尼托巴BMD注册表
William D Leslie1, Fatima Zarzour1, Neil Binkley2
1University of Manitoba, Rady College of Medicine, Winnipeg, MB R3E 0W2, Canada.
概括
在这项大型观察性研究中,老年人广泛使用的他类药物对骨矿物质密度 (BMD) 或骨质疏松症风险没有显著的益处. 研究结果表明,即使长期使用高度他类药物,也没有对骨健康产生临床意义上的影响.
科学领域:
- 老年学是一门学科.
- 药理学 药理学是指药理学的学科.
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 类药物通常被处方给老年人.
- 现有的关于他类药物对骨矿物质密度 (BMD) 和骨质疏松症风险的影响的人类数据不一致.
- 需要进一步的研究来澄清他类药物使用与骨健康之间的关联.
研究的目的:
- 在40岁及以上的个体中调查他类药物使用和骨质量之间的关联.
- 为了确定他类药物的使用是否会影响随着时间的推移BMD的变化.
- 评估长期使用高度他类药物对骨密度的影响.
主要方法:
- 来自曼尼托巴BMD计划 (1999-2018) 的数据分析.
- 包括22393名40岁以上的40岁以上的个人,基线和后续DXA扫描.
- 链接药物记录以识别他类药物使用者并评估暴露时间和坚持.
主要成果:
- 之前使用他类药物和最初的TH BMD之间没有发现显著的关联.
- 在随访期间,使用他类药物并没有显示出对 BMD 变化有显著影响.
- 即使长期使用高度他类药物 (平均5.1年),也没有观察到 BMD 或 BMD 变化的临床显著差异.
结论:
- 这项大型观察性研究发现,他类药物暴露对骨密度没有临床意义上的益处.
- 药物使用,即使是长期使用和高度坚持使用,似乎也没有改善骨矿物质密度或降低骨质疏松症风险.
- 研究结果表明,他类药物可能不会在老年人骨健康管理中发挥重要作用.
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