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用于选择性细菌破坏和骨质整合的生物灵感氨基导聚涂层

Meizhou Sun1, Chi Xu2, Ruonan Wu1

  • 1State Key Laboratory of Chemical Resource Engineering, Key Lab of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology), Ministry of Education, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, No. 15 Beisanhuan East Road, Beijing 100029, China.

Journal of the American Chemical Society
|May 29, 2025
PubMed
概括

植入物的新型一级聚涂层有效地对抗感染并增强骨整合. 这种生物灵感表面破坏细菌,促进骨细胞生长,在受感染的模型中改善骨质整合50%.

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Bacterial Signaling

Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
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