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生理学上稳定,皮层印制,双门金属有机框架药物输送系统用于瘤向组合疗法

Xingkun Luan¹, Xin Jin¹, Xiaona Li¹

¹State Key Laboratory of Coordination Chemistry, MOE Key Laboratory of Mesoscopic Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, People's Republic of China.

ACS applied materials & interfaces

|May 29, 2025

概括

我们开发了一种稳定,双门的纳米金属有机框架 (MOF) 用于向癌症治疗. 该系统精确地提供两种化疗药物,并使光动力疗法 (PDT) 能够提高治疗效率.

科学领域:

生物医学工程生物医学工程
材料科学材料科学材料科学
纳米技术纳米技术

背景情况:

纳米级金属有机框架 (MOFs) 对药物输送有希望,但在生理条件下缺乏稳定性.
富含酸盐的环境会降解MOF,限制其临床使用.
积极向的传递系统对于个性化癌症疗法至关重要.

研究的目的:

创建一个生理稳定的,表位印记的,双门的MOF药物递送系统.
为了使瘤向组合疗法使用光动力学疗法 (PDT) 和两种药物化学疗法.
加强药物向并实现逻辑关闭释放,以精确治疗癌症.

主要方法:

功能化PCN-224 (((ZrIV) MOFs与西兰酸盐和加载药物I.
利用DNA作为一个门卫 (纳米门I) 和纳米载体的药物II通过介质.
组装的ZIF-8膜 (nanogate II) 用于酸盐耐药性和癌细胞识别.

主要成果:

双门MOF系统表现出极好的生理稳定性.
通过印制的ZIF-8膜实现了对癌细胞的选择性向.
尽量减少药物过早泄漏,并启用逻辑关闭释放以提高化疗疗效.

结论:

开发的双门MOF药物系统提供了卓越的生理稳定性和积极向癌细胞.
成功实现了PDT和两种药物化疗的联合治疗.
在癌症基因疗法和核酸疫苗开发中具有广泛的应用前景.

关键词:

标本的印记标本的印记逻辑关闭释放释放的逻辑关闭释放.金属-有机的框架.生理稳定性生理稳定性针对瘤的向治疗

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