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Updated: Sep 20, 2025

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不匹配修复蛋白质 免疫在唇状细胞癌中:在唇癌发生中的作用?
Yamyle Velasquez Barragán1, Anna Clara Aragao Matos Carlos1, Gabriella Alves Juliao Costa2
1Division of Oral Pathology, Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, Ceará, Brazil.
Asian Pacific journal of cancer prevention : APJCP
|May 29, 2025
概括
不匹配修复 (MMR) 蛋白质表达在唇状细胞癌 (LSCC) 和行动性炎 (AC) 中增加. MMR蛋白质的不平衡与LSCC的进展和更差的预后相关.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 皮肤病学 皮肤病学
背景情况:
- 唇状细胞癌 (LSCC) 源于行动性炎 (AC).
- 太阳辐射影响不匹配修复 (MMR) 复杂功能.
- 没有完全理解MMR在唇癌发生中的作用.
研究的目的:
- 研究MMR蛋白 (MutSα和MutLα) 在唇癌发生中的作用.
- 评估MMR蛋白表达和正常唇表皮质,AC和LSCC的失衡.
- 为了将MMR状态与临床预后变量和组织病理特征相关联.
主要方法:
- 免疫组织化学用于评估NLE,AC和LSCC样本中的MutSα (MSH2 / MSH6) 和MutLα (MLH1 / PMS2) 表达.
- 核阳性细胞的量化和MutSα不平衡和MutLα不平衡比率的评估.
- 统计分析包括曼-惠特尼,克鲁斯卡尔-瓦利斯/恩和斯皮尔曼相关性测试.
主要成果:
- 在LSCC和AC中,MSH2,MSH6,MLH1免疫染细胞和MutSα不平衡的百分比显著增加.
- 在AC中,MutSα不平衡高于MutLα不平衡.
- 在LSCC中,晚期瘤阶段 (T3 / T4) 和结节转移与分别较高的MutSα失衡和MutLα失衡有关.
- 在AC中观察到较低的MSH6免疫化,高风险的发育不良和LSCC具有血管入侵.
- 在LSCC中增加的MMR蛋白之间发现了直接的相关性.
结论:
- 增加的MMR表达和MutSα/MutLα不平衡与唇部癌症的发展有关.
- MMR蛋白质失衡与LSCC的进展和预后有关.
- 这些发现突出了MMR蛋白质作为唇癌发生和患者结果的潜在生物标志物.
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