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大脑结构与精神病的关联
Peter Pieperhoff1, Lena Hofhansel2,3, Frank Schneider4
1Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany. p.pieperhoff@fz-juelich.de.
概括
精神病与特定区域的大脑体积减少有关,特别是那些涉及行为控制的区域. 精神病的反社会行为与大脑皮层下皮层区域中较小的体积有很强的相关性.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 脑部成像 脑部成像
背景情况:
- 精神病是持续性暴力的主要危险因素.
- 了解精神病的神经生物学基础对于干预至关重要.
研究的目的:
- 通过结构性核磁共振 (MRI) 来研究精神病的神经生物学基质.
- 为了将大脑区域的体积与精神病的尺寸相关联.
主要方法:
- 结构性MRI扫描39名男性精神病患者和匹配的对照.
- 大脑区域的体积用Julich-Brain和AAL3图谱计算.
- 心理病检查清单 (PCL-R) 评分和大脑体积之间的关联分析.
主要成果:
- PCL-R因子2 (反社会行为) 负相关性与pons,基底,乳头,基底前脑,小脑,轨道前脑,背侧前脑和岛屿皮层的体积.
- PCL-R因子1 (人际情感) 与轨道前,背侧前和海马区域的关联较弱.
- 与对照人群相比,精神病患者的总大脑体积显著减少,右侧脑部有显著差异.
结论:
- 研究结果表明,与精神病变的行为控制相关的前额子皮质回路功能障碍.
- 精神病症中的大脑结构偏差看起来是个体间的变量.
- 精神病的反社会行为与大脑皮层下皮层区域中较小的体积密切相关.
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