孕前叶酸营养摄入量与儿童遗传责任在儿童急性淋巴细胞白血病风险中的相互关系
Yijin Xiang1, Catherine Metayer2, Scott C Kogan3
1University of Southern California, Los Angeles, California.
概括
孕产妇摄入叶酸可能会降低儿童白血病的风险,特别是在拉丁裔人群中,通过抵消遗传倾向. 这凸显了个性化叶酸策略的必要性.
科学领域:
- 营养流行病学 营养流行病学
- 遗传流行病学遗传流行病学
- 儿科瘤学 儿科瘤学
背景情况:
- 产前叶酸摄入与儿童急性淋巴细胞白血病 (ALL) 风险降低有关.
- 在ALL病因学中,母亲的叶酸与孩子对叶酸缺乏症的遗传敏感性之间的相互作用尚不清楚.
研究的目的:
- 为了研究叶酸,B族维生素,同型半氨酸和儿童ALL风险之间的因果关系.
- 检查母亲的营养如何与影响ALL儿童叶酸代谢的遗传因素相互作用.
主要方法:
- 孟德尔的随机化分析使用血清叶酸,同氨酸和B族维生素的遗传仪器.
- 在两个大童年的评估ALL全基因组关联研究.
- 后勤回归用于评估孕产妇营养,多基因风险评分 (PRS) 和MTHFR基因型之间的相互作用.
主要成果:
- 较高的基因预测血清叶酸与儿童ALL风险降低有关 (OR,0.58;95% CI,0.34-0.97).
- 在拉丁裔人群中,增加周周接受的叶酸摄入量逆转了与低叶酸PRS和MTHFR rs1801133 T等位基因相关的ALL风险升高.
- 相比之下,在非拉丁裔白人中,尽管摄入叶酸,ALL的遗传风险仍然存在.
结论:
- 母亲的叶酸摄入量可以减轻对ALL的遗传易感性,但这种效果似乎是特定于种族的,仅在拉丁裔中观察到.
- 对叶酸缺乏的遗传倾向仍然是非拉丁裔白人ALL的风险因素,无论叶酸摄入量如何.
- 个性化的叶酸补充策略对于最大化益处和减轻各种人群中ALL风险至关重要.
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