生物衰老加速与内血管血栓切除术后不良结果的关联
Mingyue Qian1, Wei Wang2, Shuaiyu Chen2
1Department of Neurology, Affiliated Huishan Hospital of Xinglin College, Nantong University, Wuxi Huishan District People's Hospital, No.2 Zhanqian North Road, Wuxi, 214000, Jiangsu Province, China.
概括
现型年龄,生物衰老的衡量标准,预测缺血性中风患者接受内血管血栓切除术 (EVT) 的结果不佳. 较高的表型年龄与EVT后不良事件风险增加相关,突出其临床意义.
科学领域:
- 老年学是指老年学的学科.
- 神经学 神经学
- 生物医学科学 生物医学科学
背景情况:
- 加速衰老是已知的慢性疾病和死亡率的风险因素.
- 通过表型年龄评估的生物年龄可能会影响中风患者的临床结果.
研究的目的:
- 评估表型年龄与内血性中风患者内血管内血栓切除术 (EVT) 后临床结果之间的关联.
主要方法:
- 对745名接受EVT治疗的缺血性中风患者的回顾性分析.
- 使用PhenoAge算法计算的表型年龄.
- 后勤回归和受限制的立方线分析了与90天糟糕结果的关联 (修改的兰金尺度>2).
主要成果:
- 表型年龄与EVT后90天不良结果的更高风险显著相关 (或每年增加1.067,P<0.001).
- 证实了表型年龄和不良结果之间的剂量反应关系.
- 现型年龄最高四分之一的患者与最低四分之一相比,风险大大增加.
结论:
- 现型年龄是用EVT治疗的大血管封闭性中风患者不良结果的重要预测因素.
- 研究结果表明,生物年龄是中风恢复和预后的关键因素.
- 需要在不同的群体中进一步验证.
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