cnm阳性菌株突变菌 (Streptococcus mutans) 是牙损伤的主要病原体,可能会通过桃体加剧IgA脏病
Seigo Ito1, Taro Misaki2,3, Shuhei Naka4
1Department of Internal Medicine, Japan Self-Defense Force Iruma Hospital, Iruma, Saitama, Japan.
Clinical and experimental nephrology
|May 29, 2025
概括
阳性Cnm的Streptococcus mutans可能会通过桃体恶化IgA脏病 (IgAN). 桃体切除术可能对口服cnm阳性S. mutans.的Igan患者有益.
科学领域:
- 微生物学 微生物学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 免疫学 免疫学 免疫学
背景情况:
- 突变性链球菌 (Streptococcus mutans) 是导致牙的关键病原体.
- 生物体的Cnm蛋白与IgA脏病 (IgAN) 病原发生有关.
- 桃体切除术在具有cnm阳性S.突变体的Igan患者中的作用尚不清楚.
研究的目的:
- 调查cnm阳性S.突变体,桃体切除术和Igan临床结果之间的关联.
- 为了确定桃体切除术是否会影响患有cnm阳性S. mutans的患者的IgAN进展.
主要方法:
- 158名IGAN患者的唾液通过PCR测试了cnm阳性S.突变菌.
- 患者根据S. mutans状态和桃体切除史进行分组.
- 临床数据,包括蛋白尿,eGFR和血清IGA,在各组之间进行了比较.
主要成果:
- 组C (cnm阳性S. mutans,没有桃体切除术) 显示蛋白尿率显著更高 (>2+) 和较低的EGFR (<60毫升/分钟/1.73米2).
- 此外,C组的患者血清IgA升高 (>347 mg/dL) 的比例显著更高.
结论:
- 具有CNM阳性的S. mutans可能会加剧Igan,可能是通过桃体的参与.
- 桃体切除术可能为口腔cnm阳性S. mutans.的Igan患者提供治疗益处.
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