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中国儿童的真实生长激素治疗模式:来自两个数据库的报告

Wei Wu¹, Nan Li^2,3, Tingting Wang⁴

¹Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Advances in therapy

|May 29, 2025

概括

在中国,重组人体生长激素 (rhGH) 治疗矮身 (SS) 患者的停药率很高,许多儿童开始治疗的时间较晚. 提高坚持和遵循指导方针对于儿童生长激素治疗的更好的结果至关重要.

科学领域:

儿科儿科儿科
内分泌学在内分泌学.
药理学药理学是指药理学的学科.

背景情况:

重组人体生长激素 (rhGH) 已在中国建立,用于治疗矮身 (SS).
关于在中国儿童中RhGH治疗的有效使用和挑战的现实数据有限.

研究的目的:

调查中国儿童的rhGH治疗现状.
确定与rhGH治疗有效性和挑战相关的因素.

主要方法:

一个多中心,回顾性,观察性研究.
包括从2017年1月到2024年4月接受rhGH治疗的41,942名儿童.
收集关于基线特征,rhGH类型 (长效与短效) 和治疗遵从性的数据.

主要成果:

很大一部分儿童,特别是具有异常矮身 (ISS) 的儿童,开始以低于最佳剂量的rhGH治疗.
超过42%的儿童因不规则的服用和访问问题等原因停止了rhGH治疗.
长效的rhGH (LAGH) 与短效的rhGH (SAGH) 相比,与更长的治疗持续时间有关.

结论:

在中国,SS患者的儿童往往在较大年龄开始接受rhGH治疗.
治疗中断率高和剂量低于最佳水平对实现最佳结果构成挑战.
加强坚持和坚持指南推的治疗模式对于改善儿科SS的治疗结果至关重要.

关键词:

生长激素生长激素的作用生长激素缺乏,生长激素缺乏.异常发病的矮身症患者.重组人体生长激素的人体生长激素对于妊娠年龄来说,小的

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