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Updated: Sep 20, 2025

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
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通过CARM1-介导的MAP2K4甲基化增强了MAP2K4的致癌功能,并且在三阴性乳腺癌中构成了可向的依赖性

Eui-Jun Kim1,2, Yidan Wang1,2, Yu-Lin Chen1,2

  • 1McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin.

Cancer research
|May 29, 2025
PubMed
概括

在三阴性乳腺癌 (TNBC) 中,协活性剂相关的阿尔金因甲基转移酶1 (CARM1) 抑制激活了AKT,导致了耐药性. 将CARM1抑制剂与PI3K抑制剂结合在一起,在TNBC中显示出协同作用的抗癌效应.

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