未来的威胁:目前每年感染不到100人的动物骨髓炎病毒
Emma R Worden-Sapper1, Paul Gendler1, Rachel E Lange2
1Department of Molecular, Cellular, and Developmental Biology, University of Colorado, 1945 Colorado Avenue, Boulder, CO 80309, USA; BioFrontiers Institute, University of Colorado, 3415 Colorado Avenue, Boulder, CO 80303, USA.
Cell reports
|May 29, 2025
概括
新兴的orthoflaviviruses构成了严重的流行病威胁. 对这些被忽视的病毒的研究和诊断的发展对于防止未来的疫情至关重要.
科学领域:
- 病毒学 病毒学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 脊髓炎病毒,如登革热和寨卡病毒,有史以来出现导致人类重大疾病的历史.
- 目前,许多其他的orthoflaviviruses正处于新兴途径中,对未来的流行病或流行病构成潜在威胁.
研究的目的:
- 审查和突出研究不足的带有流行病潜力的orthoflavivirus.
- 强调对这些被忽视的病毒进行生物研究和诊断开发的迫切需要.
主要方法:
- 文献综述和25种正方形病毒感染每年少于100人的文献.
- 鉴定了12种额外的orthoflaviviruses,有人类暴露的血清学证据.
主要成果:
- 鉴定出37种具有人类流行病或流行病出现潜力的orthoflaviviruses.
- 强调了对这些病毒的大多数病毒缺乏生物知识和医疗对策.
结论:
- 在发生广泛的人类溢出之前,对新出现的orthoflavivirus进行主动研究是必不可少的.
- 开发改进的PCR和基于血清学的诊断技术对于监测和早期检测至关重要.
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