在记忆巩固和回忆过程中,前带带皮层的离线长期增强的时间窗口
Junyu Liu1, Akihiro Goto2, Yasunori Hayashi1
1Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan.
Neuroscience research
|May 29, 2025
概括
记忆巩固将情节性记忆转移到大脑皮层. 在睡眠障碍期间在前带带皮层 (ACC) 中删除长期增强 (LTP) 会影响回忆,显示LTP.
科学领域:
- 神经科学是一个神经科学.
- 记忆研究 记忆研究
- 突触性可塑性 突触性可塑性
背景情况:
- 插曲性记忆在海马中形成,并转移到皮质区域进行存储.
- 记忆巩固涉及突触可塑性,包括长期强化 (LTP).
- 在整合期间LTP的确切时间和位置尚未完全理解.
研究的目的:
- 研究前带带皮质 (ACC) 中LTP的时间动态和必要性,以巩固记忆.
- 确定 LTP 在 ACC 中影响记忆回忆的机会窗口.
主要方法:
- 开发和应用一种光遗传工具,cofilin-SuperNova (CFL-SN),用于选择性LTP删除.
- 在不同时间点内存获取后在ACC中针对性地删除LTP.
- 在LTP操纵后评估记忆回忆.
主要成果:
- 在记忆获得后的第二天,在睡眠期间在ACC中删除LTP,但在记忆回忆受损后不立即删除.
- 记忆回忆在没有干扰的单一天后是可能的.
- 在重复删除后的第八天在ACC中恢复LTP允许回忆回忆.
- 一旦内存整合完成,ACC中的LTP不需要召回.
结论:
- 在ACC中,记忆的巩固可以在较长的时间内发生,长达8天.
- 整合过程似乎在单个睡眠周期内完成.
- 在ACC中的LTP在特定的记忆巩固窗口中发挥着关键作用.
相关概念视频
Long-term Potentiation
55.9K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
55.9K
Long-Term Memory
268
Long-term memory is a relatively permanent type of memory, capable of storing vast amounts of information over extended periods. Its storage capacity is generally considered unlimited.
Long-term memory can be categorized into two primary types: explicit and implicit memory. Explicit memory, also known as declarative memory, involves the conscious recollection of information that we deliberately try to remember, recall, and articulate. This type of memory encompasses specific facts, events, and...
Long-term memory can be categorized into two primary types: explicit and implicit memory. Explicit memory, also known as declarative memory, involves the conscious recollection of information that we deliberately try to remember, recall, and articulate. This type of memory encompasses specific facts, events, and...
268
Working Memory
452
Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this...
452
Long-term Depression
2.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
Calcium Ion Concentration Mechanism
If over...
2.6K
Higher Mental Functions of Brain: Learning and Memory
977
Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
977
Role of Cerebellum and Prefrontal Cortex in Memory
607
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
607


