美洲的前欧洲接触性麻风及其目前的持续性
Maria Lopopolo1,2, Charlotte Avanzi3, Sebastian Duchene4
1Institut Pasteur, Université Paris Cité, CNRS UMR 2000, Microbial Paleogenomics Unit, Paris, France.
概括
美国的麻风病早于欧洲人的到来, 在北美和南美发现的古老菌株揭示了这种疾病在殖民之前的悠久历史.
科学领域:
- 微生物学
- 古病理学
- 遗传学
背景情况:
- 在历史上,美洲的麻风病是欧洲人引入的.
- 在美国发现了Mycobacterium lepromatosis,
研究的目的:
- 调查美洲菌的历史存在和多样性.
- 确定在欧洲殖民之前在美洲是否存在麻风菌感染.
主要方法:
- 检查了389个古人类样本和408个现代人类样本.
- 对Mycobacterium lepromatosis遗传数据进行了基因分析.
主要成果:
- 证据证实,在欧洲人接触之前,美洲的M. 麻风病感染了人类.
- 遗传学分析发现了M. lepromatosis的不同感染类型.
- 在北美和南美发现了古老的麻风菌株.
结论:
- 麻风菌在美洲有很长的历史,
- 这种病原体可能在美洲大陆广泛传播.
- 这一发现需要重新评估麻风病在美洲的引入和历史.
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