经过10年的时间,对2型糖尿病患者和正常葡萄糖耐受症患者的周围神经功能的变化
Alexander Strom1,2, Klaus Strassburger3, Dan Ziegler1
1Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine-University Düsseldorf, Germany.
2型糖尿病的周围神经功能下降与正常的葡萄糖耐受性相似,这表明衰老和初始诊断状态是关键因素,而不是糖尿病的进展. 这影响了对糖尿病神经病变进展的理解.
科学领域:
- 神经学 神经学
- 糖尿病学 糖尿病学
- 周围神经研究研究
背景情况:
- 与正常葡萄糖耐受性 (NGT) 相比,早期,控制良好的2型糖尿病中周围神经功能变化的知识有限.
- 了解NGT中神经功能的自然过程及其在早期2型糖尿病中的变化至关重要.
研究的目的:
- 在NGT患者中研究下肢小和大神经纤维功能的自然过程.
- 为了评估最近被诊断出患有良好控制的2型糖尿病的个体的外周神经功能下降.
主要方法:
- 未来5年和10年的观察性研究.
- 评估下肢外围神经功能,使用周围运动神经传导速度 (MNCV),外侧感觉神经传导速度 (SNCV),外侧感觉神经动作潜力 (SNAP),振动感知值 (VPT) 和热检测值 (TDTs).
- 使用多重线性或逻辑回归分析数据.
主要成果:
- 在基线时,与NGT组相比,在2型糖尿病组中,所有5种神经功能指标都受损.
- 5年后,在两组中都观察到人均MNCV和VPT的相似下降.
- 在较大的糖尿病队列中发现了可比的5年和10年的下降模式,与与年龄相关的变化保持一致.
结论:
- 控制良好的2型糖尿病中神经功能恶化似乎主要受到诊断时的初始神经状态和生理衰老的影响.
- 与糖尿病相关的进展可能不是神经功能下降的主要驱动因素,在2型糖尿病的早期阶段得到良好控制.
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