年龄和静止性低血压与姿势变化后的巴罗反射敏感性和脑氧化有关
Marjolein Klop1, Jurgen A H R Claassen2, Arjen Mol3
1Department of Neurobiology, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands; Department of Geriatric Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
患有正静性低血压的老年人表现出降低了巴罗反射灵敏度和大脑氧化恢复受损,增加了对大脑缺氧的易感性. 大脑自调节似乎无法弥补这些缺陷.
科学领域:
- 生理学 生理学 生理学
- 老年学是一门学科.
- 心血管研究研究心血管研究
背景情况:
- 在姿势变化期间,巴罗反射敏感度 (BRS) 和大脑自我调节对于维持血压 (BP) 和大脑血流 (CBF) 至关重要.
- 这些调节机制在老年人中可能会受到损害,特别是那些有正静性低血压 (OH) 的人,导致像跌倒和潜在的大脑缺氧这样的症状.
研究的目的:
- 为了调查年龄,性别,抗高血压药物的使用,并发症和高血压与BSR和体位变化后大脑氧化的关联.
- 评估大脑自我调节在减少BRS和OH的背景下对大脑自我调节的补偿作用.
主要方法:
- 在年轻成年人,老年人和老年门诊患者的横卧到站立过渡期间,持续测量心率,血压和大脑氧化量.
- 使用时间和频率域分析确定BRS,大脑氧化恢复和大脑自我调节.
- 使用线性回归和群组比较进行统计分析以确定关联.
主要成果:
- 增加的年龄和OH的存在与较低的BRS有显著的关联.
- 更高的年龄与增强的大脑氧化恢复相关,而OH与过渡后1分钟大脑氧化恢复减少有关.
- 在研究组中没有发现大脑自我调节的显著损害.
结论:
- 在OH患者中,减少BRS和大脑氧化恢复受损表明大脑缺氧的风险增加.
- 这些发现不支持大脑自我调节在减轻该人群中减少BRS的影响方面发挥显著的补偿作用.
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