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与焦虑的功能连接特征:静止状态功能近红外光谱学研究

Xinxin Chen^1,2,3, Jiuhong You^1,3,4, Jinmei Li⁵

¹Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.

|May 29, 2025

概括

功能近红外光谱 (fNIRS) 显示,患者与无焦虑患者之间的静止状态功能连接 (RSFC) 没有显著差异. 建议对更大样本进行进一步的研究,以探索fNIRS在这个患者群体中的能力.

科学领域:

神经科学是一个神经科学.
医疗成像医学成像
精神病学是一个精神病学.

背景情况:

经常伴随着焦虑障碍.
了解和焦虑中的大脑连接对于有效管理至关重要.
使用fNIRS的休息状态功能连接 (RSFC) 提供了一种研究大脑网络的非侵入性方法.

研究的目的:

通过使用fNIRS. 调查患有和没有焦虑的患者之间脑皮层RSFC的差异.
探索fNIRS在识别与中焦虑相关的神经生理学标志物的潜力.

主要方法:

功能近红外光谱学 (fNIRS) 用于测量38名患者的RSFC.
患者被划分为焦虑和非焦虑组,基于通用焦虑障碍7项评分.
在大脑皮层的六个感兴趣区域 (ROI) 中分析了RSFC.

主要成果:

在焦虑和非焦虑组之间没有发现总体组平均RSFC强度的统计学上显著差异.
虽然在纠正之前观察到一些区域连接差异,但在错误发现率 (FDR) 纠正后,这些差异并没有保持显著.
fNIRS展示了作为一种成像工具的潜力,用于在患者中检查RSFC.

结论:

在这项研究中,静止状态fNIRS在患者和无焦虑患者之间脑功能连接中没有显著差异.
更大的样本大小和任务状态fNIRS范式可能是必要的,以检测微妙的差异.
使用fNIRS的持续研究可以为患有并发性焦虑症的患者提供更好的诊断和治疗策略.

关键词:

焦虑是一种焦虑.是一种.在FNIRS中使用.静止状态的功能连接.

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