骨的原发性腺癌:一个病例报告
Pei Qin1, Chunben Xu, Yuetao Zhao
1Department of Oncology, No. 923 Hospital of PLA, Nanning, Guangxi Zhuang Autonomous Region, China.
Medicine
|May 29, 2025
概括
本案例研究表明,对于罕见的原发性盆腺癌,多模式治疗方法,结合手术,化疗和免疫检查点抑制剂 (ICI) 延长晚期疾病的存活时间.
科学领域:
- 在瘤学瘤学.
- 腎臟病學 (nephrology) 是一種醫學.
- 免疫治疗是一种免疫疗法.
背景情况:
- 骨的原发性腺癌是一种罕见的,具有挑战性诊断和不良预后的侵袭性恶性瘤.
- 现有的治疗选择有限,需要探索新的治疗策略.
研究的目的:
- 介绍一个先进的初级脏盆腔腺癌病例,该病例采用多模式治疗方法进行管理.
- 评估结合激进手术,化疗和免疫检查点抑制剂 (ICI) 的疗效.
主要方法:
- 一名61岁的男性患有晚期脏盆腔腺癌,接受了腹腔镜激进脏切除术与部分囊切除术.
- 术后治疗包括辅助化疗,基于ICI的顺序治疗方案 (tislelizumab,toripalimab) 和向治疗 (lenvatinib).
- 使用了治疗适应,毒性管理和生物标志物监测 (CA19-9).
主要成果:
- 患者在初始组合治疗后通过淋巴结回归实现了部分反应,并使CA19-9水平正常化.
- 尽管疾病复发和进展,包括肺转移,连续治疗方案和重新挑战导致了长时间的生存.
- 患者存活了28个月,东部合作性瘤组的绩效状态为1.
结论:
- 整合手术,化疗和ICI的多式疗法对于优化晚期盆腺癌的存活率至关重要.
- 为了克服抗性,需要动态的治疗适应,包括重新挑战疗程和组合疗法.
- 积极的毒性管理和生物标志物驱动的监测对于平衡疗效和安全至关重要.
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