在25(OH) D参考区间的地理差异
Efsane Yavuz1, Mustafa Örkmez1, Mehmet Akif Bildirici2
1Gaziantep University, Faculty of Medicine, Department of Medical Biochemistry, Gaziantep, Turkey.
概括
维生素D缺乏是一个全球性的健康问题. 这项研究确定了25...OH) D的区域和季节性参考范围,发现水平通常低于推值.
科学领域:
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
- 临床化学 临床化学
背景情况:
- 维生素D缺乏是全球严重的健康问题.
- 确定25-氧维生素D (25(OH) D的准确参考范围对于诊断和管理至关重要.
- 区域和季节性变化,受地理和饮食的影响,影响维生素D水平.
研究的目的:
- 为了确定维生素D (25(OH) D和相关参数 (PTH,Ca,P,ALP) 的参考间隔.
- 为了比较建立这些参考范围的直接和间接方法.
- 研究维生素D水平的区域 (东南安纳托利亚与黑海) 和季节性 (夏季与冬季) 差异.
主要方法:
- 利用直接和间接的方法计算25(OH) D. 的参考范围.
- 在直接方法中使用非参数方法 (CLSI EP28-A3).
- 应用数据过和Bhattacharya方法用于间接方法.
主要成果:
- 直接方法25(OH) D参考间隔因地区和季节而异 (例如,东南亚纳托利亚:夏季8.03-29.44 ng/mL,冬季5.55-23.07 ng/mL).
- 间接方法25(OH) D参考间隔为7.24-41.69 ng/mL (南亚纳托利亚) 和6.17-42.66 ng/mL (黑海).
- 严重维生素D缺乏的患病率在不同地区和季节的范围从7.6%到30.5%.
结论:
- 对于25...OH) D的参考范围显示出显著的区域和季节性变化.
- 该研究强调,研究群体中的25...OH) D水平经常低于推范围.
- 准确的,特定区域的参考间隔对于解决维生素D缺乏症至关重要.
关键词:
25 (((OH) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D)直接方法 直接方法在EP28-A3cc中使用.间接方法 间接方法参考时间间隔 (RI)更多相关视频
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