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The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
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Measures of variability are statistical metrics that reveal the dispersion pattern within a dataset. They are pivotal in biostatistics, providing insights into the heterogeneity within health and biological data. Variability signifies the degree to which data points diverge from one another, helping researchers understand the potential range of values and associated uncertainty within the data.
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在25(OH) D参考区间的地理差异.

Efsane Yavuz1, Mustafa Örkmez1, Mehmet Akif Bildirici2

  • 1Gaziantep University, Faculty of Medicine, Department of Medical Biochemistry, Gaziantep, Turkey.

The Journal of steroid biochemistry and molecular biology
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PubMed
概括

维生素D缺乏是一个全球性的健康问题. 这项研究确定了25...OH) D的区域和季节性参考范围,发现水平通常低于推值.

关键词:
25 (((OH) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D)直接方法 直接方法在EP28-A3cc中使用.间接方法 间接方法参考时间间隔 (RI)

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科学领域:

  • 内分泌学 在内分泌学.
  • 公共卫生 公共卫生
  • 临床化学 临床化学

背景情况:

  • 维生素D缺乏是全球严重的健康问题.
  • 确定25-氧维生素D (25(OH) D的准确参考范围对于诊断和管理至关重要.
  • 区域和季节性变化,受地理和饮食的影响,影响维生素D水平.

研究的目的:

  • 为了确定维生素D (25(OH) D和相关参数 (PTH,Ca,P,ALP) 的参考间隔.
  • 为了比较建立这些参考范围的直接和间接方法.
  • 研究维生素D水平的区域 (东南安纳托利亚与黑海) 和季节性 (夏季与冬季) 差异.

主要方法:

  • 利用直接和间接的方法计算25(OH) D. 的参考范围.
  • 在直接方法中使用非参数方法 (CLSI EP28-A3).
  • 应用数据过和Bhattacharya方法用于间接方法.

主要成果:

  • 直接方法25(OH) D参考间隔因地区和季节而异 (例如,东南亚纳托利亚:夏季8.03-29.44 ng/mL,冬季5.55-23.07 ng/mL).
  • 间接方法25(OH) D参考间隔为7.24-41.69 ng/mL (南亚纳托利亚) 和6.17-42.66 ng/mL (黑海).
  • 严重维生素D缺乏的患病率在不同地区和季节的范围从7.6%到30.5%.

结论:

  • 对于25...OH) D的参考范围显示出显著的区域和季节性变化.
  • 该研究强调,研究群体中的25...OH) D水平经常低于推范围.
  • 准确的,特定区域的参考间隔对于解决维生素D缺乏症至关重要.