诊断和治疗Candida内炎和胆膜炎的治疗方法
Nitipong Permpalung1, Sarah Sedik2, Peter G Pappas3
1Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
概括
候群内 (CE) 和胆红素炎需要改进诊断和治疗策略. 本综述综合了当前的知识,以指导临床医生管理这些危及视力的真菌眼部感染.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 医学真菌学 医学真菌学
背景情况:
- 候群内炎 (CE) 和胆红素炎是候群病的严重眼部并发症,造成视力丧失的重大风险.
- 管理受到不一致的指导方针,有限的证据和可变的临床实践的挑战.
- 埃奇诺坎丁引入后,EC的患病率略有增加,突出显示需要有效的干预措施.
研究的目的:
- 综合关于Candida内和胆炎的当前知识,以建立一个全面的临床框架.
- 解决诊断方面的挑战,包括眼镜镜检查,成像和微生物学方法.
- 审查治疗策略,包括全身和静脉内抗真菌药物,手术选择和监测.
主要方法:
- 在PubMed,Embase和Scopus进行了广泛的文献搜索.
- 专注于流行病学,致病性,诊断,治疗和眼球角膜炎的结果.
- 主要传染病和眼科学会的审查指南.
主要成果:
- 间接眼镜镜是视网膜可视化的标准;OCT和 fundus 摄影提供辅助支持.
- 通过玻璃体采样进行微生物学确认是确定的,但由于真菌负担较低,往往很困难.
- 新兴的诊断方法,如基于CRISPR的真菌DNA测试,显示出有希望的结果;人工智能工具尚未对CE进行验证.
结论:
- 改善CE结果需要协调查,及时的眼科治疗和多学科合作.
- 未来的研究应该完善诊断算法,优化治疗持续时间,并澄清新型诊断的作用.
- 利用远程医疗和先进的成像技术可以提高眼球角膜病的早期检测和监测.
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