在吸烟者中的4 - 氨基基的膀致癌风险评估:源到结果的研究研究
Huanhuan Zhu1, Qi Xiao2, Huilin Zhang2
1Departments of Environmental Genomics and Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, Center for Global Health, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China; School of Public Health, Zhejiang International Science and Technology Cooperation Base of Air Pollution and Health, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
香烟烟雾中的4-aminobiphenyl (4-ABP) 通过诱导DNA损伤和血管生成促进膀癌. 吸烟者表现出更高的4-ABP水平,突出了其在致癌过程中的毒理学意义.
科学领域:
- 环境毒理学环境毒理学
- 化学致癌发生的原因
- 分子生物学分子生物学
背景情况:
- 4-氨基双 (4-ABP) 是一种与膀癌相关的环境致癌物.
- 它的环境和毒理途径在很大程度上仍未被探索.
- 香烟烟雾是4-ABP暴露的重要来源.
研究的目的:
- 阐明4-ABP的环境和毒理学科学.
- 为4-ABP建立一个总体暴露途径 (AEP).
- 为4-ABP诱导的膀癌构建一个不良结局途径 (AOP).
主要方法:
- 在文献中搜索 (PubMed,科学网,MEDLINE) 来构建AEP.
- 构建AOP的生物信息工具.
- 在体外测试中使用膀癌细胞 (J82) 和内皮细胞 (HUVECs).
- 用于风险评估的基准剂量 (BMD) 分析.
主要成果:
- 4-ABP存在于香烟烟雾中,在吸烟者中含量更高.
- 4-ABP诱导DNA损伤,细胞循环停止,并促进血管生成.
- 血管生成的BMDL5为0.02mM,人类相当剂量为0.44μg/kg/天.
结论:
- 4-ABP在吸烟者中诱导膀癌,主要是通过促进血管生成.
- 这项研究为评估膀致癌的化学风险提供了一个框架.
- 这些发现强调了了解4-ABP在吸烟相关癌症中的作用的重要性.
更多相关视频
11:02Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
09:50Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette Smoke
Published on: February 12, 2015
相关概念视频
Mutagenicity and Carcinogenicity
Criteria for Causality: Bradford Hill Criteria - II
Cancer Prevention
Some...
Statistical Methods for Analyzing Epidemiological Data
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
