雌激素受体低阳性乳腺癌:历史观点和最近的进展
Huina Zhang1, Madhurya Ramineni1, Xiaoxian Li2
1Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, 14624, USA.
Human pathology
|May 29, 2025
概括
低ER阳性乳腺癌 (1-10%的ER染色) 提出了独特的挑战. 本综述探讨了它的生物学,病理学和临床影响,强调了这种侵略性亚型的治疗不确定性.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 内分泌学 在内分泌学.
背景情况:
- 对雌激素受体 (ER) 表达的评估对于预测乳腺癌内分泌治疗反应至关重要.
- 低ER阳性乳腺癌,定义为1-10%的ER染色 (2020年ASCO/CAP指南),是一种独特的亚型.
- 这些瘤表现出异质性和经常具有攻击性行为,类似于ER阴性癌症.
研究的目的:
- 为提供ER低阳性乳腺癌的全面审查.
- 分析最近了解瘤生物学,病理评估和临床影响方面的进展.
- 讨论确定这种患者群体最佳治疗策略所面临的挑战.
主要方法:
- 关于传统ER评估方法 (联结试验,免疫组织化学) 的文献综述.
- 对ER低阳性乳腺癌特征的新兴证据的分析.
- 综合了关于临床病理特征,分子概况,预后和治疗反应的数据.
主要成果:
- 低ER阳性乳腺癌是异质的,具有不同的特征和预后.
- 这些瘤经常表现出侵略性的临床行为.
- 内分泌治疗在低ER阳性乳腺癌中的疗效仍然不确定.
结论:
- 低ER阳性乳腺癌需要进一步调查,因为其具有攻击性和不确定的治疗结果.
- 准确的病理评估和对瘤生物学的理解至关重要.
- 确定ER低阳性乳腺癌的最佳治疗策略是一个持续的临床挑战.
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