针治疗刺激性肠综合征的有效性 (ACTION):一个多中心随机对照试验
Jing-Wen Yang1, Ling-Yu Qi1, Shi-Yan Yan1
1International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China.
针在患有刺激性肠综合征 (IBS-D) 的患者中显著改善了腹痛和腹. 这种治疗在18周内显示出持续的疗效,为IBS-D管理提供了潜在的替代疗法.
科学领域:
- 胃肠病学 胃肠病学
- 综合医学是一个整体的医学.
- 临床试验 临床试验
背景情况:
- 刺激性肠综合征 (IBS) 很普遍,影响了4.1%的成年人,许多人经历了持续的症状,对标准治疗没有反应.
- 针是一种常见的IBS治疗方法,但支持其有效性的强有力的临床证据仍然有限.
- 腹占主导地位的IBS (IBS-D) 在患者管理中提出了重大挑战.
研究的目的:
- 评估针作为诊断为腹主导性IBS (IBS-D) 的患者治疗的有效性.
- 评估针对关键IBS-D症状的影响,包括腹痛和便一致性.
主要方法:
- 一个多中心随机对照试验,涉及280名患有IBS-D (罗马IV标准) 的患者,遍及中国6家医院.
- 参与者被随机分配 (1:1) 在6周内接受15次真正针或假针,随后进行12周的随访期.
- 主要结局指标是第6周的复合反应率,定义为腹痛的改善和腹日数的减少.
主要成果:
- 针组在明显更高的率 (57.9%) 与假针组相比 (41.4%) 实现了主要结果,风险比率为1.40 (P = .008).
- 群体之间的统计学意义上的差异在第3周出现,并在整个研究期间保持,除了第16周.
- 在试验期间没有报告任何严重不良事件,这表明IBS-D患者针的安全性概况有利.
结论:
- 针在减轻腹部疼痛和改善便一致性方面表现出有效性,对于患有IBS-D的人来说.
- 针治疗IBS-D的治疗益处持续了18周.
- 这些发现表明,针可以被认为是管理IBS-D的可行的替代治疗选择.
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