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Updated: Jun 16, 2025

X-Ray Crystallography to Study the Oligomeric State Transition of the Thermotoga maritima M42 Aminopeptidase TmPep1050
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X-Ray Crystallography to Study the Oligomeric State Transition of the Thermotoga maritima M42 Aminopeptidase TmPep1050

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希斯200的形状灵活性使得碳酸二醇酶II的T200H突变体中的催化活性成为可能

Seon Woo Lim1, Hannah Jeong1, Gwang Ho Kim1

  • 1Department of Physics, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea.

Molecules and cells
|May 29, 2025
PubMed
概括

在二氧化碳无水酶II (CAII) 中的T200H突变破坏了活性部位,但由于His200的灵活性,保留了部分功能. 这种在CAII催化中的动态守门员作用为酶工程提供了洞察力.

关键词:
活动现场的水力动态.碳酸无水酶是一种碳酸无水酶.酶的机制 酶的机制一个中间状态.局部导向的突变发生.

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