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伴随性酒精使用障碍和艾滋病毒中的疼痛:一个网络元分析研究

Muhammed Bishir¹, Mohamed Sheik Tharik Abdul Azeeze¹, Sulie L Chang¹

¹Institute of NeuroImmune Pharmacology, Seton Hall University, South Orange, NJ, 07079, USA.

Alcohol (Fayetteville, N.Y.)

|May 29, 2025

概括

酒精使用通过激活神经炎症和神经病痛路径,使艾滋病毒感染者 (PWH) 的疼痛恶化. 这项研究将酒精消费和艾滋病毒与增加的不适和神经肌肉疾病联系在一起.

科学领域:

神经科学是一个神经科学.
免疫学免疫学免疫学
遗传学是一个遗传学.

背景情况:

艾滋病毒感染者 (PWH) 饮酒很常见,他们经常用酒来控制疼痛.
虽然短期接触酒精可以减轻疼痛,但长期使用与慢性疼痛有关.
艾滋病毒感染本身与疼痛和神经系统并发症有关.

研究的目的:

研究艾滋病毒的背景下,酒精暴露如何影响疼痛信号通路.
分析暴露于酒精的,HIV-1Tg大鼠和HIV阳性患者的基因组数据,以了解疼痛的分子机制.

主要方法:

分析了三个大脑基因组数据集 (马卡卡木拉塔,HIV-1Tg大鼠,艾滋病毒患者).
机智路径分析 (IPA) - - 核心分析以识别激活/抑制的信号路径.
在不同表达基因 (DEGs) 上对乙醇暴露的in-silico模拟.

主要成果:

暴露于酒精和艾滋病毒感染激活了和HIV-1Tg大鼠的神经炎症和神经病痛途径.
在HIV患者中,神经炎症被激活,而神经病痛信号被抑制,神经肌肉疾病增加.
体模拟显示,暴露于酒精会在艾滋病毒背景下加剧不适和神经肌肉疾病.

结论:

酒精消费和艾滋病毒感染通过调节神经炎症和神经病痛信号来协同促进疼痛.
酒精使用导致艾滋病毒感染者的疼痛加剧和神经肌肉疾病.
研究结果强调了酒精对PWH患者疼痛管理的有害影响.

关键词:

不同表达的基因不适的感觉不适的感觉在GSE47474和GSE28160中使用.基因表达综合系统 GSE6968585 创造力路径分析神经肌肉疾病与神经病变.

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