孤立核心抗体阳性乙型肝炎患者的慢性病:NHANES 2017-2020研究中的风险分析
Ke Mi1, Tingdan Ye1, Calvin Q Pan2
1Center of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
概括
单独的乙型肝炎核心抗体 (HBcAb) 阳性与美国成年人的慢性病 (CKD) 风险没有积极关联. 然而,年龄较大和血清尿素的升高与该组中较高的CKD风险有关.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 肝病学 肝病学是一种肝病学.
- 流行病学 流行病学
背景情况:
- 孤立的乙型肝炎核心抗体 (HBcAb) 阳性和慢性病 (CKD) 之间的联系正在争论中.
- 一些研究表明乙型肝炎病毒 (HBV) 感染与CKD风险增加之间存在联系,而其他研究则提出了不确定的发现.
- 这项研究调查了美国人口中孤立的HBcAb阳性和CKD之间的关联.
研究的目的:
- 评估单独的HBcAb阳性和美国成年人中CKD的流行率之间的关联.
- 在单独的HBcAb阳性个体中识别CKD的风险因素.
主要方法:
- 分析了2017-2020年NHANES周期中成年参与者的数据.
- 将参与者分为孤立的HBcAb阳性和非感染组.
- 使用后勤回归模型来评估单独的HBcAb阳性和CKD之间的关联,并使用多变量分析来确定风险因素.
主要成果:
- 与未感染组 (5.2%) 相比,孤立的HBcAb阳性组 (7.9%) 的CKD患病率更高.
- 未经调整的分析表明,随着单独的HBcAb阳性 (OR=1.25) 增加了CKD风险,但经过调整的分析显示了相反的关联 (OR=0.76).
- 在孤立的HBcAb阳性个体中,年龄较大和血清尿素 (BUN) 升高与更高的CKD风险有关,而高等教育与风险降低有关.
结论:
- 尽管单独的HBcAb阳性组中CKD患病率较高,但在调整后没有发现与CKD风险的积极关联.
- 高龄和BUN水平升高是该人群中CKD的重要风险因素.
- 研究结果强调需要针对HBV感染患者进行个性化监测和管理策略,特别是针对抗病毒疗法和治愈后的随访.
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